“Profil
Stabilitas Tetrasiklin”
Tetrasiklin memiliki 3 pKa
yaitu :
- pKa 1 : 3,3
- pKa 2 : 7,7
- pKa 3 : 9,5
1. Profil Stabilitas
Tetrsiklin pKa :3,3
Rumus yang digunakan :
% terionisasi = 100 ____
1 + antilog (pKa – pH)
pH : 0
% terionisasi = 100 ___
1 + antilog (3,3 – 0)
= 0,050
pH : 1
% terionisasi = 100 ___
1 + antilog (3,3 – 1)
= 0,498
pH : 2
% terionisasi = 100 ___
1 + antilog (3,3 – 2)
= 4,773
pH : 3
% terionisasi = 100 ___
1 + antilog (3,3 – 3)
= 33,386
pH : 4
% terionisasi = 100 ___
1 + antilog (3,3 – 4)
= 83,366
pH : 5
% terionisasi = 100 ___
1 + antilog (3,3 – 5)
= 98,044
pH : 6
% terionisasi = 100 ___
1 + antilog (3,3 – 6)
= 99,800
pH : 7
% terionisasi = 100 ___
1 + antilog (3,3 –7)
= 99,980
pH : 8
% terionisasi = 100 ___
1 + antilog (3,3 – 8)
= 99,998
pH : 9
% terionisasi = 100 ___
1 + antilog (3,3 – 9)
= 99,999
pH : 10
% terionisasi = 100 ____
1 + antilog (3,3 – 10)
= 99,9998
pH : 11
% terionisasi = 100 ____
1 + antilog (3,3 – 11)
= 99,9999
pH : 12
% terionisasi = 100 ____
1 + antilog (3,3 – 12)
= 99,99998
pH : 13
% terionisasi = 100 ____
1 + antilog (3,3 – 13)
= 99,99999
pH : 14
% terionisasi = 100 ____
1 + antilog (3,3 – 14)
= 100
Tabel profil stabilitas tetrasiklin pKa 3,3
|
no
|
pH
|
% terionisasi
|
|
1.
|
0
|
0,05
|
|
2.
|
1
|
0,498
|
|
3.
|
2
|
4,773
|
|
4.
|
3
|
33,386
|
|
5.
|
4
|
83,366
|
|
6.
|
5
|
98,044
|
|
no
|
pH
|
% terionisasi
|
|
7.
|
6
|
99,8
|
|
8.
|
7
|
99,98
|
|
9.
|
8
|
99,998
|
|
10.
|
9
|
99,999
|
|
11.
|
10
|
99,9998
|
|
12.
|
11
|
99,9999
|
|
13.
|
12
|
100
|
|
14.
|
13
|
100
|
|
15.
|
14
|
100
|
Kurva Stabilitas Tetrasiklin pKa 3,3
Rumus yang digunakan :
% terionisasi = 100 ____
1 + antilog (pKa – pH)
pH : 0
% terionisasi = 100 ____
1 + antilog
(7,7 – 0)
= 1,99X10-6
pH : 1
% terionisasi = 100 ____
1 + antilog
(7,7– 1)
= 1,99X10-5
pH : 2
% terionisasi = 100 ____
1 + antilog
(7,7– 2)
= 1,99X10-4
pH : 3
% terionisasi = 100 ____
1 + antilog
(7,7– 3)
= 1,99X10-3
pH : 4
% terionisasi = 100 ____
1 + antilog
(7,7– 4)
= 1,99X10-2
pH : 5
% terionisasi = 100 ____
1 + antilog
(7,7– 5)
= 0,199
pH : 6
% terionisasi = 100 ____
1 + antilog
(7,7– 6)
= 1,956
pH : 7
% terionisasi = 100 ____
1 + antilog
(7,7– 7)
= 16,634
pH : 8
% terionisasi = 100 ____
1 + antilog
(7,7– 8)
= 66,614
pH : 9
% terionisasi = 100 ____
1 + antilog
(7,7– 9)
= 95,227
pH : 10
% terionisasi = 100 ____
1 + antilog (7,7– 10)
= 99,501
pH : 11
% terionisasi = 100 ____
1 + antilog (7,7– 11)
= 99,949
pH : 12
% terionisasi = 100 ____
1 + antilog (7,7– 12)
= 99,9995
pH : 13
% terionisasi = 100 ____
1 + antilog (7,7– 13)
= 99,99998
pH : 14
% terionisasi = 100 ____
1 + antilog (7,7– 14)
= 99,99999
Tabel profil stabilitas tetrasiklin pKa 7,7
|
no
|
pH
|
% terionisasi
|
|
1.
|
0
|
1,99X10-6
|
|
2.
|
1
|
1,99X10-5
|
|
3.
|
2
|
1,99X10-4
|
|
4.
|
3
|
1,99X10-3
|
|
5.
|
4
|
1,99X10-2
|
|
6.
|
5
|
0,199
|
|
7.
|
6
|
1,956
|
|
8.
|
7
|
16,634
|
|
9.
|
8
|
66,614
|
|
10.
|
9
|
95,227
|
|
11.
|
10
|
99,501
|
|
12.
|
11
|
99,949
|
|
13.
|
12
|
99,9995
|
|
14.
|
13
|
99,99998
|
|
15.
|
14
|
99,99999
|
Kurva Stabilitas Tetrasiklin pKa 7,7
3. Profil Stabilitas
Tetrsiklin pKa :9,5
Rumus yang digunakan :
% terionisasi = 100 ____
1 + antilog (pKa – pH)
pH : 0
% terionisasi = 100 ____
1 + antilog
(9,5 – 0)
= 3,16X10-8
pH : 1
% terionisasi = 100 ____
1 + antilog
(9,5– 1)
= 3,16X10-7
pH : 2
% terionisasi = 100 ____
1 + antilog
(9,5– 2)
= 3,16X10-6
pH : 3
% terionisasi = 100 ____
1 + antilog
(9,5– 3)
= 3,16X10-5
pH : 4
% terionisasi = 100 ____
1 + antilog
(9,5– 4)
= 3,16X10-4
pH : 5
% terionisasi = 100 ____
1 + antilog
(9,5– 5)
= 3,16X10-3
pH : 6
% terionisasi = 100 ____
1 + antilog
(9,5– 6)
= 3,16X10-2
pH : 7
% terionisasi = 100 ____
1 + antilog
(9,5– 7)
= 0,316
pH : 8
% terionisasi = 100 ____
1 + antilog
(9,5– 8)
= 3,065
pH : 9
% terionisasi = 100 ____
1 + antilog
(9,5– 9)
= 24,026
pH : 10
% terionisasi = 100 ____
1 + antilog (9,5– 10)
= 75,975
pH : 11
% terionisasi = 100 ____
1 + antilog (9,5– 11)
= 96,936
pH : 12
% terionisasi = 100 ____
1 + antilog (9,5– 12)
= 99,687
pH : 13
% terionisasi = 100 ____
1 + antilog (9,5– 13)
= 99,946
pH : 14
% terionisasi = 100 ____
1 + antilog (9,5– 14)
= 99,999
Tabel profil stabilitas tetrasiklin pKa 9,5
|
no
|
pH
|
% terionisasi
|
|
1.
|
0
|
3,16X10-8
|
|
2.
|
1
|
3,16X10-7
|
|
3.
|
2
|
3,16X10-6
|
|
4.
|
3
|
3,16X10-5
|
|
5.
|
4
|
3,16X10-4
|
|
6.
|
5
|
3,16X10-3
|
|
7.
|
6
|
3,16X10-2
|
|
8.
|
7
|
0,316
|
|
9.
|
8
|
3,065
|
|
10.
|
9
|
24,026
|
|
11.
|
10
|
75,975
|
|
12.
|
11
|
96,936
|
|
13.
|
12
|
99,687
|
|
14.
|
13
|
99,946
|
|
15.
|
14
|
99,999
|
Kurva Stabilitas Tetrasiklin pKa 9,5
No comments:
Post a Comment