CASE IV
A.
Patient
Description
- Name : MYPM
- Age : 59 years
- Reg. No : 552069
- Gender : Male
- Admission : 13/10/06
- Weight : 104 kg (IBW=66.1)
- Race : Malay
- Heights : 170 cm
B. Chief Complaint
(CC)
Chest
pain: +severe, typical, Left arm numbness for 1 day
+ Sweating
+ Nausea
C. History of
present illness (HPI)
Known history of IHD (3 vessel disease with
occluded SVE)
Planned for PCI in December 2006
On 16/2/06, NYHA I-II, TIMI score 4/7
CABGs were done on 1986 & 1995
D. Family & Social
History
n
Father and mother has history of Ischemic heart
disease and Diabetes Mellitus.
n
Staying with family member.
n
None smoker or alcoholic user
n
Pensioner from Penang Hospital
as attendant.
E. Medical History
Interview
HEART PROBLEMS:
|
URINARY/REPRODUCTIVE:
|
||
Chest pain (angina)
|
ü
|
Urinary or bladder
infection
|
|
Past heart attack
|
ü
|
Prostate problems
|
|
Heart failure
|
Hysterectomy
|
||
Irregular heartbeat
|
Chronic yeast infections
|
||
Heart by-pass surgery
|
ü
|
Kidney disease
|
|
Rheumatic fever
|
Dialysis
|
||
Other:
|
Other:
|
||
EYES, EARS, NOSE &
THROAT
|
MUSCLES AND BONES
|
||
Poor vision
|
Arthritis
|
||
Poor hearing
|
Gout
|
||
Glaucoma
|
Back pain
|
||
Sinus problem
|
Amputation
|
||
Bladder disorder
|
Joint replacement
|
||
Other:
|
Other:
|
||
GASTROINTESTINAL
|
NEUROLOGICAL
|
||
Heartburn
|
Headache
|
||
Ulcer
|
Seizures or epilepsy
|
||
Constipation
|
Parkinson’s disease
|
||
Diverticulitis
|
Dizziness
|
||
Liver disease
|
Past stroke
|
||
Gallbladder problems
|
Fainting
|
||
Pancreatitis
|
Depression
|
||
Other:
|
Anxiety
|
||
Other:
|
|||
DO YOU HAVE:
|
LUNG PROBLEMS
|
||
High blood pressure
|
ü
|
Asthma
|
|
Low blood pressure
|
Emphysema
|
||
High cholesterol
|
ü
|
Bronchitis
|
|
Diabetes
|
ü
|
Other:
|
|
Cancer
|
|||
Anaemia
|
|||
Bleeding disorder
|
DO YOU HAVE OR USE…? |
||
Hay fever
|
Glasses
|
||
Sleeping problems
|
Hearing aid
|
||
Other:
|
Other:
|
||
DO YOU HAVE A FAMILY
HISTORY OF:
|
|||
High blood pressure
|
|||
Heart disease
|
ü
|
Other:Stroke
|
|
Diabetes
|
ü
|
F.S.1
|
Current Prescription Medication Regimen |
|||||||
Name/Dose/Strength/Route
|
Schedule/
Frequency of Use
|
Indication
|
Start Date (and stop date if applicable)
|
Prescriber
|
Indication issues, effectiveness, safety,
compliance and cost
|
|||
T.
Aspirin 150mg
|
OD
|
Antiplatelet
|
Con’t
|
|||||
T.
Metoprolol 100mg
|
BD
|
Hypertention/IHD
|
Con’t
|
|||||
T.
Isorsobide Dinitrate 10mg
|
TDS
|
IHD
|
Con’t
|
|||||
T.
Vastarel 20mg
|
TDS
|
IHD
|
Con’t
|
|||||
T.
Valsartan 80mg
|
OD
|
Hypertension/IHD
|
Con’t
|
|||||
T.
Simvastatin 10mg
|
OD
|
Dyslipidaemia
|
Con’t
|
|||||
T.
Metformin 1g
|
BD
|
Diabetes mellitus
|
Con’t
|
|||||
T.
Gliclazide 80mg
|
OD
|
Diabetes mellitus
|
Con’t
|
|||||
F.S.2
|
Current Nonprescription Medication
Regimen (OTC, herbal, homeopathic, nutritional, etc)
|
|||||||
Name/Dose/Strength/Route
|
Schedule/
Frequency of Use
|
Indication
|
Start Date (and stop date if applicable)
|
Prescriber
|
Indication issues, effectiveness, safety,
compliance and cost
|
|||
Nil
|
||||||||
F.
Allergies:
History of allergies: Yes [
] No known allergies [ü]
Are you allergic to any prescription
drugs, over-the-counter medication, herbals or food supplements?If yes, please list the medications
and type of allergic
reaction experienced:_______________
Are there any medications
that you are not allergic but cannot tolerate?
[ ]Yes
[ü] No If yes,
please list the medications and the reaction experienced:
What
environmental allergies do you have?
Nil
G. Medication
Compliance assessment
Base questions on
history obtained to this point.
Your medication
regimen sounds complex and must be hard to follow;
How often would
you estimate that you miss a dose?
Seldom
Everyone has
problems with following a medication regimen exactly as written.
What are the
problems you are having with your regimen?
Claimed
tolerate well by patient.
Compliance
rate: Compliant [ü ] Moderate/partial
compliant [ ] Noncompliant [ ]
H. Social History
Smoking : Ex-smoker
Alcohol : Non alcoholic user
Other drug
use : -
Caffeine
intake : 3 cups (≈100ml) per week
Diet
|
Routine Exercise/Recreation
|
Daily Activities/Timing
|
Low salt – moderate compliance
|
Daily brisk walking
|
Routine exercise, mild to
moderate daily activities.
|
Low fat diet
|
||
Diabetic diet – compliance
|
J. Physical examination / laboratory for initial and
follow-up.
Date
|
13/10/06
|
Date
|
13/10/06
|
Height(cm)
|
170 cm
|
Na+ (mmol/L)
|
137
|
Weight(kg)
|
104 kg
|
K+ (mmol/L)
|
4.1
|
Temp(C°)
|
37.0
|
BUN (mmol/L)
|
6.4
|
BP(mmHg)
|
147/86
|
Creatinine (umol/L)
|
105
|
Pulse(bpm)
|
82
|
Urine output
|
-
|
RR/VENT
|
20
|
I/O
|
-
|
Peak Flow
|
-
|
Uric acid/Mg (mmol/L)
|
-
|
pH
|
-
|
Ca2+ (mmol/L)
|
-
|
SPO2
|
-
|
PO4 (mmol/L)
|
-
|
PCO2
|
-
|
FBS (mmol/L)
|
8.7 (17/10/06)
|
HCO
|
-
|
BMI
|
36
|
LDL (mmol/L)
|
1.8 (19/9/06)
|
LDH (U/L)
|
164
|
HDL (mmol/L)
|
0.9 (19/9/06)
|
CK (U/L)
|
87
|
TG (mmol/L)
|
2.1 (19/9/06)
|
INR
|
1.1
|
T.Chol (mmol/L)
|
3.7 (19/9/06)
|
PT/aPTT
|
12.8/25.4
|
WBC (x103/uL)
|
8.3
|
TT/FDP
|
|
Hgb (g/dL)
|
13.9
|
Total Bili (umol/L)
|
12
|
Platelet (x103/uL)
|
234
|
Hct
|
41.9
|
ALT/AST (U/L)
|
ALT:73 ; AST:49
|
||
Alk Phos (g/L)
|
61
|
||
X-ray
|
Total Protein (g/L)
Albumin (g/L)
|
71
40
|
|
Echocardio
|
EF 33% (15/10/06)
|
TSH
|
-
|
ECG
|
Lead I, II Q wave
|
HbA1c (6.8-8.6)-Fair
control
>8.6%- Poor control
|
8.6% (17/10/06)
|
Pharmalogic review of system:
General:
Alert, conscious, chest pain, left arm numbness, +sweating
Vital
Signs: BP 147/86 mmHg ; PR 82bpm ; T 37.0 °C
;
KUT:
-
HEPATIC:
No hepatomegaly
CVS: DRNM
CHEST: Lungs clear
BLOOD: WNL
ABDO: Soft, non tender, no organomegaly
SKIN/MUSCLE: -
NEURO/MENTAL: -
HEENT: -
K. Physical Examination/ Daily Progress (D1-D4)
|
||||
13/10/06
|
14/10/06
|
15/10/06
|
16/10/06
|
|
General
|
Alert,
conscious, complaint of chest pain (severe, typical), left arm numbness,
+sweating, +Nausea
|
Still complaint of chest pain, left sided, no
shortness of breath
|
Alert, conscious, no more chest pain
|
Comfortable,afebrile
|
Vital Sign
|
||||
BP (mmHg)
|
147/86
|
126/80
|
137/87
|
157/71
|
Pulse (bpm)
|
82
|
61
|
68
|
65
|
Temp (oC)
|
37.0
|
37.0
|
37.0
|
37.0
|
CVS
|
DRNM
|
DRNM
|
DRNM
|
S1S2
|
Lungs
|
Clear
|
Clear
|
Clear
|
Clear
|
ECG
|
Q
wave at lead I, II
|
No ischemic changes
|
-
|
--
|
Physician Plan
|
1.
T. Plavix 300mg
stat, then 75mg OD
2.
S/L T. GTN 1/1
stat
3.
IV Morphine
2.5mg stat
4.
IV
Metoclopromide 10mg stat
5.
SC Clexane
(Enoxaparin) 80mg stat & BD x 3/7 Patient refuse sc Clexane
6.
Change to IV
Heparin bolus 5000 U, then 1000U infusion/hour
7.
NP O2 3L/min
|
1.
↑IV Heparin to 1200U/hour and review APTT
2.
↑T. Gliclazide 160mg BD
3.
↑IV Heparin to 1300U/hour (11.55pm)
4.
Start IV Isoket 1mg/hour & inform if BP<100/60 (11.55pm)
|
1.
Off IV Isoket
2.
Off Nasal Prong
3.
Continue
Hepatin & keep INR 1.5-2.5 (should be APTT not INR, written by houseman)
|
1.
↑ IV Heparin to 1600U/hour
2.
↑ T. Isosorbide dinitrate 20mg TDS
3.
Add Gemfibrozil 300mg BD
4.
Plan PCI (LAD) in December
|
K. Physical Examination/ Daily Progress
(D5-D6)
|
||
17/10/06
|
18/10/06
|
|
General
|
Afebrile,
comfortable
|
+ chest pain, afebrile
|
Vital Sign
|
||
BP (mmHg)
|
132/68
|
113/68
|
Pulse (bpm)
|
62
|
83
|
Temp (oC)
|
37.0
|
37.0
|
CVS
|
S1S2,
DRNM
|
S1S2
|
Lungs
|
Clear
|
Clear
|
ECG
|
-
|
-
|
Physician Plan
|
1.
↑ IV Heparin to 1800U/hour
2.
Continue others
3.
Check APTT on 12 noon
|
1.
↑ IV Heparin to 2000U/hour
2.
Off Heparin
3.
PCI on 11/12/06
4.
Discharge patient today
|
L. Laboratory findings and follow up:
13/10/06
15:53
|
13/10/06
21:56
|
14/10/06
10:49
|
14/10/06
19:39
|
15/10/06
08:40
|
15/10/06
22:11
|
16/10/06
17:31
|
17/10/06
08:55
|
17/10/06
14:57
|
||
PT
|
11.5-13.5
sec
|
12.8
|
13.4
|
13.4
|
12.7
|
12.7
|
13.7
|
13.0
|
13.0
|
12.9
|
INR
|
0.8-1.2
|
1.1
|
1.1
|
1.1
|
1.1
|
1.1
|
1.1
|
1.1
|
1.1
|
1.1
|
APTT
|
24.0-35.0
sec
|
25.4
|
34.8
|
25.3
|
30.7
|
28.0
|
31.0
|
43.8
|
61.6
|
41.2
|
Action
|
Baseline
|
Start IV Heparin
|
↑ IV Heparin to
1300U/hour
|
↑ IV Heparin to
1400U/hour
|
↑ IV Heparin to
1600U/hour
|
↑ IV Heparin to
1800U/hour
|
L. Laboratory findings and follow up:
Test
|
Normal Range
|
13/10/06
|
14/10/06
|
15/10/06
|
16/10/06
|
17/10/06
|
18/10/06
|
WBC
|
5.2-12.4 x 10^3/uL
|
8.3
|
-
|
-
|
-
|
-
|
-
|
RBC
|
4.2-5.4 x 10^6/uL
|
4.6
|
-
|
-
|
-
|
-
|
-
|
HGB
|
12
-16 g/dL
|
13.9
|
-
|
-
|
-
|
-
|
-
|
HCT
|
37
– 47 %
|
41.9
|
-
|
-
|
-
|
-
|
-
|
MCV
|
81
– 99 fL
|
91.9
|
-
|
-
|
-
|
-
|
-
|
MCHC
|
33
– 37 g/dL
|
33.2
|
-
|
-
|
-
|
-
|
-
|
PLT
|
130
– 400 10^3/uL
|
234
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|||
Na+
|
135-145 mmol/L
|
137
|
-
|
-
|
-
|
-
|
-
|
K+
|
3.5-5.0 mmol/L
|
4.1
|
-
|
-
|
-
|
-
|
-
|
Urea
|
1.7-8.3 mmol/L
|
6.4
|
-
|
-
|
-
|
-
|
-
|
Creat
|
57-130 umol/L
|
105
|
-
|
-
|
-
|
-
|
-
|
Cl-
|
86-108
|
101
|
-
|
-
|
-
|
-
|
-
|
CLcr
|
75-125ml/min
|
62.61
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|||
T Pro
|
66-87g/L
|
71
|
-
|
-
|
-
|
-
|
-
|
Alb
|
35-52
g/l
|
40
|
-
|
-
|
-
|
-
|
-
|
Glb
|
23-35
g/l
|
31
|
-
|
-
|
-
|
-
|
-
|
A/G
|
0.9-1.8
|
1.3
|
-
|
-
|
-
|
-
|
-
|
T Bili
|
0-24mmol/l
|
12
|
-
|
-
|
-
|
-
|
-
|
ALT
|
0-42
U/l
|
73
|
-
|
-
|
-
|
-
|
-
|
ALP
|
34-104
g/l
|
61
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|||
AST
|
0-37
U/L
|
38
|
49
|
46
|
-
|
-
|
-
|
CK
|
24-195
U/L
|
87
|
67
|
71
|
-
|
-
|
-
|
LDH
|
135-225
U/L
|
164
|
168
|
205
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|||
T Chol
|
<5.2
mmol/L
|
3.7 (19/9)
|
-
|
-
|
-
|
-
|
-
|
TG
|
<1.8
mmol/L
|
2.1 (19/9)
|
-
|
-
|
-
|
-
|
-
|
LDL
|
<3.36
mmol/L
|
1.8 (19/9)
|
-
|
-
|
-
|
-
|
-
|
HDL
|
>1.29
mmol/L
|
0.9 (19/9)
|
-
|
-
|
-
|
-
|
-
|
%HDL-Chol
|
15-25
|
24 (19/9)
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|||
Reflomet
|
mmol/L
|
-
|
-
|
8.2
|
8.9
|
9.4
|
|
FBG
|
mmol/L
|
-
|
-
|
-
|
8.7
|
-
|
|
HbA1c
|
6.8-8.6%-Fair control
>8.6%-Poor control
|
-
|
-
|
-
|
8.6
|
-
|
K
.Diagnoses/Provisional Dx / Acute / Chronic medical Problems
[1] Unstable Angina
[2] Hypertension
[3] Type II Diabetes Mellitus
[4] Ischemic Heart Disease (COROS
showed 3VD)
L. Drug treatment in the ward
Current Drug Therapy (Oral, Parenteral,
Inhaler and others)
|
||||
Drug Name/ Dose/
Strength /Route
|
Schedule
|
Duration
|
Indication
|
|
Start
|
Stop
|
|||
T. Aspirin 150mg
|
OD
|
cont
|
cont
|
|
T. Metoprolol 100mg
|
BD
|
cont
|
cont
|
|
T.Isorsobide Dinitrate 10mg
|
TDS
|
cont
|
16/10/06
|
|
T.Isorsobide Dinitrate 20mg
|
TDS
|
16/10/06
|
cont
|
|
SL GTN 1/1
|
STAT
|
13/10/06
|
13/10/06
|
|
IV Morphine 2.5mg
|
STAT
|
13/10/06
|
13/10/06
|
|
IV Metoclopromide 10mg
|
STAT
|
13/10/06
|
13/10/06
|
|
T. Vastarel 20mg
|
TDS
|
cont
|
cont
|
|
T. Valsartan 80mg
|
OD
|
cont
|
cont
|
|
T. Simvastatin 10mg
|
ON
|
cont
|
cont
|
|
T. Metformin 1g
|
BD
|
cont
|
cont
|
|
T. Gliclazide 80mg
|
OD
|
cont
|
14/10/06
|
|
T. Gliclazide 160mg
|
BD
|
14/10/06
|
cont
|
|
T. Plavix 300mg
stat & 75mg
|
OD
|
13/10/06
|
cont
|
|
C. Gemfibrozil 300mg
|
BD
|
16/10/06
|
cont
|
|
IV Isoket 1mg/hr
|
Infusion
|
14/10/06
|
15/10/06
|
|
IV Heparin 5000U Bolus, then 1000U/hr
|
Infusion
|
13/10/06
|
14/10/06
|
|
IV Heparin 1200U/hr
|
Infusion
|
14/10/06
|
14/10/06
|
|
IV Heparin 1300U/hr
|
Infusion
|
14/10/06
|
16/10/06
|
|
IV Heparin 1600U/hr
|
Infusion
|
16/10/06
|
17/10/06
|
|
IV Heparin 1800U/hr
|
Infusion
|
17/10/06
|
18/10/06
|
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